| # | Joueur | Club | Buts | B/match |
|---|---|---|---|---|
| 1 | Lautaro Martínez | Inter | 17 | 0.45 |
| 2 | D. Malen | Roma | 14 | 0.37 |
| 3 | A. Douvikas | Como 1907 | 14 | 0.37 |
| 4 | Marcus Thuram-Ulien | Inter | 13 | 0.34 |
| 5 | R. Hojlund | Napoli | 13 | 0.34 |
| 6 | Nico Paz | Como 1907 | 12 | 0.32 |
| 7 | Keinan Davis | Udinese | 11 | 0.29 |
| 8 | Giovanni Simeone | Torino | 11 | 0.29 |
| 9 | Kenan Yıldız | Juventus | 10 | 0.26 |
| 10 | Nikola Krstović | Atalanta | 10 | 0.26 |
| 11 | Scott McTominay | Napoli | 10 | 0.26 |
| 12 | F. Bonazzoli | Cremonese | 10 | 0.26 |
| 13 | Gianluca Scamacca | Atalanta | 10 | 0.26 |
| 14 | Riccardo Orsolini | Bologna | 10 | 0.26 |
| 15 | Hakan Çalhanoğlu | Inter | 9 | 0.24 |
| 16 | Andrea Pinamonti | Sassuolo | 9 | 0.24 |
| 17 | Rafael Leão | Milan | 9 | 0.24 |
| 18 | M. Pellegrino | Parma | 9 | 0.24 |
| 19 | Christian Pulisic | Milan | 8 | 0.21 |
| 20 | Domenico Berardi | Sassuolo | 8 | 0.21 |
