| # | Joueur | Club | Buts | B/match |
|---|---|---|---|---|
| 1 | Lautaro Martínez | FC Internazionale Milano | 17 | 0.46 |
| 2 | Marcus Thuram-Ulien | FC Internazionale Milano | 13 | 0.35 |
| 3 | Donyell Malen | AS Roma | 13 | 0.35 |
| 4 | Anastasios Douvikas | Como 1907 | 13 | 0.35 |
| 5 | Nico Paz | Como 1907 | 12 | 0.32 |
| 6 | Rasmus Højlund | SSC Napoli | 12 | 0.32 |
| 7 | Giovanni Simeone | Torino FC | 11 | 0.30 |
| 8 | Kenan Yıldız | Juventus FC | 10 | 0.27 |
| 9 | Nikola Krstović | Atalanta BC | 10 | 0.27 |
| 10 | Keinan Davis | Udinese Calcio | 10 | 0.27 |
| 11 | Scott McTominay | SSC Napoli | 10 | 0.27 |
| 12 | Gianluca Scamacca | Atalanta BC | 10 | 0.27 |
| 13 | Riccardo Orsolini | Bologna FC 1909 | 10 | 0.27 |
| 14 | Hakan Çalhanoğlu | FC Internazionale Milano | 9 | 0.24 |
| 15 | Andrea Pinamonti | US Sassuolo Calcio | 9 | 0.24 |
| 16 | Rafael Leão | AC Milan | 9 | 0.24 |
| 17 | Federico Bonazzoli | US Cremonese | 9 | 0.24 |
| 18 | Domenico Berardi | US Sassuolo Calcio | 8 | 0.22 |
| 19 | Christian Pulisic | AC Milan | 8 | 0.22 |
| 20 | Mateo Pellegrino | Parma Calcio 1913 | 8 | 0.22 |